Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes-A Systematic Review

Int J Mol Sci. 2023 Apr 28;24(9):8027. doi: 10.3390/ijms24098027.


Preterm premature rupture of membranes, leading to preterm birth, is associated with neonatal and maternal morbidity and mortality. The study aimed to review the existing data on the best predictive value of pregnancy latency for known biomarkers in pregnancies after preterm premature rupture of membranes. The following databases were screened for the purposes of this systematic review: Pubmed/MEDLINE, Web of Science, EMBASE, Scopus, and the Cochrane Library. The study was conducted according to the PRISMA guidelines for systematic reviews. Only a few studies assessed biomarkers predicting pregnancy duration after PPROM. IL-6, IL-8, CRP, IL1RA, s-endoglin, βhCG, AFP, PCT, urea, creatinine, oxygen radical absorbance capacity, MDA, lipocalin-2, endotoxin activity, MMP-8, MMP-9 and S100 A8/A9 were found to have a positive predictive value for delivery timing prediction. Proinflammatory biomarkers, such as IL-6 or CRP, proved to be best correlated with delivery timing, independent of the occurrence of intrauterine infection.

Keywords: PPROM; PTB; biomarker; biomarkers; chorioamnionitis; pregnancy latency; preterm birth; preterm delivery; preterm premature rupture of membranes; timing to delivery.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Biomarkers
  • Female
  • Fetal Membranes, Premature Rupture* / diagnosis
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Interleukin-6
  • Pregnancy
  • Premature Birth* / diagnosis


  • Interleukin-6
  • Biomarkers

Grants and funding

This research received no external funding.