Linking asymmetric cell division, CD8+ T cell fate, and signal strength

Cell Rep. 2023 May 30;42(5):112548. doi: 10.1016/j.celrep.2023.112548. Epub 2023 May 12.

Abstract

Through live imaging of CD8+ T cells carrying a fate reporter, Gräbnitz et al. directly linked (a)symmetric division to T cell fate.1 Asymmetry during the first division ensured the generation of stem-like CD8+ T cells following strong T cell stimulation.

MeSH terms

  • Asymmetric Cell Division*
  • CD8-Positive T-Lymphocytes*
  • Cell Differentiation