Future therapeutic implications of new molecular mechanism of colorectal cancer

World J Gastroenterol. 2023 Apr 28;29(16):2359-2368. doi: 10.3748/wjg.v29.i16.2359.


High incidence (10.2%) and mortality (9.2%) rates led to the ranking of colorectal cancer (CRC) as the second most malignant tumor spectrum worldwide in 2020. Treatment strategies are becoming highly dependent on the molecular characteristics of CRC. The classical theories accept two models depicting the origin of CRC: The progression of adenoma to cancer and transformation from serrated polyps to cancer. However, the molecular mechanism of CRC development is very complex. For instance, CRCs originating from laterally spreading tumors (LST) do not adhere to any of these models and exhibit extremely serious progression and poor outcomes. In this article, we present another possible pathway involved in CRC development, particularly from LST, with important molecular characteristics, which would facilitate the design of a novel strategy for targeted therapy.

Keywords: Cancerous mechanism; Colorectal cancer; Golgi fragmentation; Laterally spreading tumors; Molecular mechanism; Truncated adenomatous polyposis coli mutation.

Publication types

  • Editorial

MeSH terms

  • Adenoma* / pathology
  • Colonic Polyps* / pathology
  • Colorectal Neoplasms* / epidemiology
  • Colorectal Neoplasms* / genetics
  • Colorectal Neoplasms* / therapy
  • Humans
  • Hyperplasia
  • Proto-Oncogene Proteins B-raf


  • Proto-Oncogene Proteins B-raf