Objectives: The objective is to examine the associations between serum copper, selenium, zinc, and serum estradiol (E2) among 2388 female participants from the National Health and Nutrition Examination Survey (NHANES).
Methods: To estimate the association between serum copper, selenium, zinc, and serum E2, multivariate logistic regression analyses were conducted. Fitted smoothing curves and generalized additive models were also performed.
Results: After adjusting for confounding factors, it was found that female serum copper was positively correlated with serum E2. The relationship between serum copper and E2 showed an inverted U-shaped curve (inflection point: 28.57 μmol/L). Serum selenium in women was negatively correlated with serum E2, and in the subgroup of women aged 25-55, the relationship between serum selenium and E2 showed an inverted U-shaped curve (inflection point: 1.39 μmol/L). There was no correlation between serum zinc and serum E2 in women.
Conclusions: Our study revealed a correlation between serum copper and selenium and serum E2 in women and identified an inflection point for each.
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