Exosome and epithelial-mesenchymal transition: A complex secret of cancer progression

Rajib Dhar; Arikketh Devi; Sukhamoy Gorai; Saurabh Kumar Jha; Athanasios Alexiou; Marios Papadakis

doi:10.1111/jcmm.17755

Exosome and epithelial-mesenchymal transition: A complex secret of cancer progression

J Cell Mol Med. 2023 Jun;27(11):1603-1607. doi: 10.1111/jcmm.17755. Epub 2023 May 15.

Authors

Rajib Dhar¹, Arikketh Devi¹, Sukhamoy Gorai², Saurabh Kumar Jha^{3

4

5}, Athanasios Alexiou^{6

7}, Marios Papadakis⁸

Affiliations

¹ Cancer and Stem Cell Biology Laboratory, Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, India.
² Rush University Medical Center, Chicago, Illinois, USA.
³ Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, India.
⁴ Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, India.
⁵ Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun, India.
⁶ Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, New South Wales, Australia.
⁷ AFNP Med, Wien, Austria.
⁸ Department of Surgery II, University Hospital Witten-Herdecke, Witten, Germany.

Abstract

This short communication will enlighten the readers about the exosome and the epithelial-mesenchymal transition (EMT) related to several complicated events. It also highlighted the therapeutic potential of exosomes against EMT. Exosome toxicology, exosome heterogeneity, and a single exosome profiling approach are also covered in this article. In the future, exosomes could help us get closer to cancer vaccine and precision oncology.

Keywords: anti-metastasis therapeutic development; cancer; epithelial to mesenchymal transition; metastasis; organ-specific metastasis.

MeSH terms

Epithelial-Mesenchymal Transition
Exosomes*
Humans
Neoplasms*
Precision Medicine
Signal Transduction