Prevalence and the associated factors of cognitive impairment among people living with HIV in Taiwan: a cross-sectional study

AIDS Care. 2023 Nov;35(11):1647-1653. doi: 10.1080/09540121.2023.2206094. Epub 2023 May 15.


Cognitive impairment impacts the quality of life and increases morbidity and mortality rates. The prevalence of and factors associated with cognitive impairment have become important issues as the age of people living with HIV(PLWH) increases. In 2020, We conducted a cross-sectional study to survey the cognitive impairment among PLWH in three hospitals in Taiwan with Alzheimer Disease-8 (AD8) questionnaire. The average age of 1,111 individuals was 37.54 ± 10.46 years old, and their average duration to live with HIV was 7.12 ± 4.85 years. The rate of impaired cognitive function was 2.25% (N = 25) when AD8 score ≥ 2 was a positive finding for cognitive impairment. Aging (p = .012), being less educated (p = 0.010), and having a longer duration to live with HIV (p = .025) were significantly associated with cognitive impairment. Multivariate logistic regression analysis revealed that only the duration of living with HIV was a significant factor related to the tendency of cognitive impairment (p = .032). The risk of cognitive impairment increased by 1.098 times for every additional year to live with HIV. In conclusion, the prevalence of cognitive impairment among PLWH in Taiwan was 2.25%. Healthcare personnel should be sensitive to the changes in PLWH's cognitive function as they age.

Keywords: AD8; Cognitive function; HIV; dementia; screening.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cognitive Dysfunction* / complications
  • Cognitive Dysfunction* / epidemiology
  • Cross-Sectional Studies
  • HIV Infections* / complications
  • HIV Infections* / epidemiology
  • HIV Infections* / psychology
  • Humans
  • Middle Aged
  • Prevalence
  • Quality of Life
  • Taiwan / epidemiology