Aneuploidy in Bowen's disease

Br J Dermatol. 1986 Jun;114(6):691-4. doi: 10.1111/j.1365-2133.1986.tb04877.x.

Abstract

Distinct aneuploid clones of keratinocytes were detected in six cases of cutaneous Bowen's disease. As Bowen's disease is an accepted precursor of malignancy, aneuploidy may prove to be a useful indicator of the risk of invasive change in dermatoses questionably pre-malignant.

MeSH terms

  • Aneuploidy*
  • Bowen's Disease / analysis
  • Bowen's Disease / genetics*
  • Bowen's Disease / pathology
  • Carcinoma, Squamous Cell / genetics*
  • DNA, Neoplasm / analysis
  • Female
  • Flow Cytometry
  • Humans
  • Male
  • Neoplasm Invasiveness
  • Prognosis
  • Skin Neoplasms / analysis
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology

Substances

  • DNA, Neoplasm