Urinary angiotensinogen is associated with albuminuria in adults with sickle cell anaemia

Br J Haematol. 2023 Aug;202(3):669-673. doi: 10.1111/bjh.18862. Epub 2023 May 15.

Abstract

We explored the association of novel urinary biomarkers with albumin-creatinine ratio (ACR) in adults with sickle cell anaemia. Of 37 participants, 13 (35.2%) had persistent albuminuria (PA). Urinary levels of clusterin (p = 0.002), retinol-binding protein 4 (p = 0.008), alpha-1 microglobulin (p = 0.002) and angiotensinogen (p = 0.006) were significantly higher in participants with PA than in those without PA. Although univariate analysis showed significant associations between both alpha-1 microglobulin (p = 0.035) and angiotensinogen (p = 0.0021) with ACR, only angiotensinogen was associated with ACR in multivariable analysis (p = 0.04). Our results suggest that urinary angiotensinogen may identify sickle cell anaemia patients at risk for kidney disease.

Keywords: alpha-1 microglobulin; angiotensinogen; clusterin; persistent albuminuria; retinol-binding protein 4; sickle cell disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Albuminuria / urine
  • Anemia, Sickle Cell*
  • Angiotensinogen / urine
  • Biomarkers / urine
  • Creatinine / urine
  • Humans
  • Kidney Diseases* / urine

Substances

  • Angiotensinogen
  • Biomarkers
  • Creatinine