"Shadow of a Doubt"-The Pathogenic Role of Endometrial Defects in Endometriosis Development and Endometriosis-Associated Infertility: Robust Demonstration of Clinical Relevance Is Still Urgently Needed

Paola Viganò; Maíra Casalechi; Paolo Vercellini; Edgardo Somigliana

doi:10.3390/biom13040651

"Shadow of a Doubt"-The Pathogenic Role of Endometrial Defects in Endometriosis Development and Endometriosis-Associated Infertility: Robust Demonstration of Clinical Relevance Is Still Urgently Needed

Biomolecules. 2023 Apr 5;13(4):651. doi: 10.3390/biom13040651.

Authors

Paola Viganò¹, Maíra Casalechi², Paolo Vercellini^{3

4}, Edgardo Somigliana^{3

4}

Affiliations

¹ Infertility Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 28, 20122 Milan, Italy.
² Division of Human Reproduction, Hospital das Clínicas-Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil.
³ Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy.
⁴ Gynecology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Abstract

Endometriosis is an estrogen-dependent chronic inflammatory disease characterized by the presence of endometrial glands and stroma associated with fibrosis outside the uterine cavity [...].

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Clinical Relevance
Endometriosis* / complications
Endometriosis* / pathology
Endometrium / pathology
Estrogens
Female
Humans
Infertility* / pathology

Substances

Estrogens

Grants and funding

This study was funded by Italian Ministry of Health—Current research IRCCS; M.C. acknowledges the support of Coordenação de Aperfeiçoamento de Pessoal do Nível Superior-Brasil (CAPES)—Finance Code 001.