A note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control

Biometrics. 1986 Mar;42(1):183-6.


Shirley (1977, Biometrics 33, 386-389) proposed a nonparametric version of Williams' test for determining the lowest dose level at which there is evidence of a toxic effect. A modification of Shirley's procedure is now proposed, which improves its power.

MeSH terms

  • Animals
  • Animals, Laboratory
  • Biometry
  • Dose-Response Relationship, Drug
  • Drug-Related Side Effects and Adverse Reactions*
  • Models, Biological*