Response to Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice"

Eduardo A Albornoz; Richard Gordon; Vinod Kumar; Avril A B Robertson; Kate Schroder; Trent M Woodruff

doi:10.1126/scitranslmed.adh0604

Response to Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice"

Sci Transl Med. 2023 May 17;15(696):eadh0604. doi: 10.1126/scitranslmed.adh0604. Epub 2023 May 17.

Authors

Eduardo A Albornoz¹, Richard Gordon^{2

3}, Vinod Kumar¹, Avril A B Robertson⁴, Kate Schroder⁵, Trent M Woodruff¹

Affiliations

¹ School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD 4072, Australia.
² UQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Herston, QLD 4029, Australia.
³ Translational Research Institute, School of Biomedical Science, Centre for Microbiome Research, School of Biomedical Science, Queensland University of Technology, Brisbane QLD 4102, Australia.
⁴ School of Chemistry and Molecular Biosciences, Faculty of Science, University of Queensland, St Lucia, QLD 4072, Australia.
⁵ Institute for Molecular Bioscience (IMB) Centre for Inflammation and Disease Research, University of Queensland, St Lucia, QLD 4072, Australia.

PMID: 37196062
DOI: 10.1126/scitranslmed.adh0604

Abstract

We have replicated our original finding of elevated cleaved caspase-1 in mouse brains and neuroprotection by an NLRP3 inflammasome inhibitor in two mouse models of Parkinson's disease.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Dopamine
Inflammasomes*
Mice
NLR Family, Pyrin Domain-Containing 3 Protein
Parkinson Disease* / pathology
alpha-Synuclein

Substances

Inflammasomes
alpha-Synuclein
NLR Family, Pyrin Domain-Containing 3 Protein
Dopamine