Clinical and Epidemiologic Profile of Invasive Pneumococcal Disease in Australian Children Following the Relaxation of Nonpharmaceutical Interventions Against SARS-COV-2

Pediatr Infect Dis J. 2023 Sep 1;42(9):e341-e342. doi: 10.1097/INF.0000000000003972. Epub 2023 May 18.


A global resurgence of invasive pneumococcal disease (IPD) has been noted in children. We provide a detailed clinical and epidemiological analysis of IPD in Australian children following relaxation of nonpharmaceutical interventions against coronavirus disease 2019, revealing significant morbidity and mortality-even in vaccinated children without known predisposing risk factors. Almost half of the IPD cases were caused by serotypes not covered by the 13-valent pneumococcal conjugate vaccine.

MeSH terms

  • Australia / epidemiology
  • COVID-19* / complications
  • COVID-19* / epidemiology
  • COVID-19* / prevention & control
  • Child
  • Humans
  • Incidence
  • Infant
  • Pneumococcal Infections* / epidemiology
  • Pneumococcal Infections* / etiology
  • Pneumococcal Infections* / prevention & control
  • Pneumococcal Vaccines
  • SARS-CoV-2
  • Serogroup
  • Streptococcus pneumoniae
  • Vaccines, Conjugate


  • Pneumococcal Vaccines
  • Vaccines, Conjugate