Failure to Normalize Biventricular Function Is Associated with Extracorporeal Membrane Oxygenation Use in Neonates with Congenital Diaphragmatic Hernia

J Pediatr. 2023 Sep:260:113490. doi: 10.1016/j.jpeds.2023.113490. Epub 2023 May 16.


We examined postnatal echocardiograms for 62 infants with congenital diaphragmatic hernia born from 2014 through 2020. Left and right ventricular dysfunction on D0 were sensitive, whereas persistent dysfunction on D2 was specific for extracorporeal membrane oxygenation requirement. Biventricular dysfunction had the strongest association with extracorporeal membrane oxygenation. Serial echocardiography may inform prognosis in congenital diaphragmatic hernia.

Keywords: ECMO; left ventricular dysfunction; pulmonary hypertension; right ventricular dysfunction.

MeSH terms

  • Echocardiography
  • Extracorporeal Membrane Oxygenation*
  • Hernias, Diaphragmatic, Congenital* / complications
  • Hernias, Diaphragmatic, Congenital* / diagnostic imaging
  • Hernias, Diaphragmatic, Congenital* / therapy
  • Humans
  • Infant
  • Infant, Newborn
  • Prognosis
  • Retrospective Studies