18F-FDG PET/CT in the Management of Osteosarcoma

J Nucl Med. 2023 Jun;64(6):842-851. doi: 10.2967/jnumed.123.265592. Epub 2023 May 18.


Osteosarcoma is the most common type of primary malignant bone tumor. 18F-FDG PET/CT is useful for staging, detecting recurrence, monitoring response to neoadjuvant chemotherapy, and predicting prognosis. Here, we review the clinical aspects of osteosarcoma management and assess the role of 18F-FDG PET/CT, in particular with regard to pediatric and young adult patients.

Keywords: 18F-FDG PET; clinical outcome; osteosarcoma; prediction; staging.

Publication types

  • Review

MeSH terms

  • Bone Neoplasms* / diagnostic imaging
  • Bone Neoplasms* / therapy
  • Child
  • Fluorodeoxyglucose F18 / therapeutic use
  • Humans
  • Neoplasm Staging
  • Osteosarcoma* / diagnostic imaging
  • Osteosarcoma* / therapy
  • Positron Emission Tomography Computed Tomography
  • Positron-Emission Tomography
  • Radiopharmaceuticals / therapeutic use
  • Young Adult


  • Fluorodeoxyglucose F18
  • Radiopharmaceuticals