Postural Orthostatic Tachycardia Syndrome in COVID-19: A Contemporary Review of Mechanisms, Clinical Course and Management

Bharat Narasimhan; Arundhati Calambur; Errol Moras; Lingling Wu; Wilbert Aronow

doi:10.2147/VHRM.S380270

Postural Orthostatic Tachycardia Syndrome in COVID-19: A Contemporary Review of Mechanisms, Clinical Course and Management

Vasc Health Risk Manag. 2023 May 12:19:303-316. doi: 10.2147/VHRM.S380270. eCollection 2023.

Authors

Bharat Narasimhan¹, Arundhati Calambur², Errol Moras³, Lingling Wu⁴, Wilbert Aronow⁵

Affiliations

¹ Department of Cardiology, Debakey Cardiovascular Institute, Houston Methodist, Houston, TX, USA.
² University of California San Diego, La Jolla, CA, USA.
³ Department of Medicine, Icahn School of Medicine; Mount Sinai, New York, NY, USA.
⁴ Department of Medicine, East Carolina University, Greenvile, NC, USA.
⁵ Department of Cardiology, Westchester Medical Center, Valhalla, NY, USA.

Abstract

The long-term implications of COVID-19 have garnered increasing interest in recent months, with Long-COVID impacting over 65 million individuals worldwide. Postural orthostatic tachycardia syndrome (POTS) has emerged as an important component of the Long-COVID umbrella, estimated to affect between 2 and 14% of survivors. POTS remains very challenging to diagnose and manage - this review aims to provide a brief overview of POTS as a whole and goes on to summarize the available literature pertaining to POTS in the setting of COVID-19. We provide a review of available clinical reports, outline proposed pathophysiological mechanisms and end with a brief note on management considerations.

Keywords: COVID-19; POTS; long COVID; review.

Publication types

Review

MeSH terms

COVID-19* / diagnosis
Disease Progression
Humans
Post-Acute COVID-19 Syndrome
Postural Orthostatic Tachycardia Syndrome* / diagnosis
Postural Orthostatic Tachycardia Syndrome* / epidemiology
Postural Orthostatic Tachycardia Syndrome* / therapy