Treatment with ketoconazole in diabetic patients with vaginal candidiasis

Drugs Exp Clin Res. 1986;12(5):413-4.

Abstract

Thirty-two diabetic patients with vaginal candidiasis were treated orally with 400 mg ketoconazole once daily for five days. At the end of the treatment period symptoms had disappeared and cultures for Candida were negative in 18 patients; a total of 28 reported improved symptoms. One month later 15 patients were still negative for Candida and 24 showed improved symptoms. The remaining 8 repeated the course of treatment; 6 became negative while 2 cases remained refractory to treatment. It was concluded that these encouraging results and low relapse rates indicate ketoconazole as a drug of first choice for candidiasis in patients with predisposing conditions such as diabetes.

MeSH terms

  • Administration, Oral
  • Adult
  • Candidiasis / drug therapy*
  • Candidiasis, Chronic Mucocutaneous / complications
  • Candidiasis, Chronic Mucocutaneous / drug therapy*
  • Diabetes Complications*
  • Drug Evaluation
  • Female
  • Humans
  • Ketoconazole / therapeutic use*
  • Middle Aged

Substances

  • Ketoconazole