Calreticulin exposure orchestrates innate immunosurveillance

Emma Guilbaud; Guido Kroemer; Lorenzo Galluzzi

doi:10.1016/j.ccell.2023.04.015

Calreticulin exposure orchestrates innate immunosurveillance

Cancer Cell. 2023 Jun 12;41(6):1014-1016. doi: 10.1016/j.ccell.2023.04.015. Epub 2023 May 18.

Authors

Emma Guilbaud¹, Guido Kroemer², Lorenzo Galluzzi³

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
² Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
³ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. Electronic address: deadoc80@gmail.com.

PMID: 37207656
DOI: 10.1016/j.ccell.2023.04.015

Abstract

Calreticulin (CALR) exposure on the cell surface is known to deliver robust pro-phagocytic signals to myeloid cells. In Nature, Sen Santara et al. demonstrate that surface-exposed CALR also operates as an endogenous activator of natural killer (NK) cells. Collectively, these findings suggest that CALR exposure orchestrates multiple facets of innate immunosurveillance.

MeSH terms

Calreticulin* / genetics
Calreticulin* / metabolism
Humans
Monitoring, Immunologic
Mutation
Myeloid Cells* / metabolism
Phagocytes

Substances

Calreticulin