Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model

Neurosci Biobehav Rev. 2023 Aug:151:105235. doi: 10.1016/j.neubiorev.2023.105235. Epub 2023 May 18.


Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia has progressed remarkably in recent years. Despite this, current accounts of fibromyalgia fail to capture the complex, dynamic, and mutual crosstalk between neurophysiological and psychosocial domains. We conducted a comprehensive review of the existing literature in order to: a) synthesize current knowledge on fibromyalgia; b) explore and highlight multi-level links and pathways between different systems; and c) build bridges connecting disparate perspectives. An extensive panel of international experts in neurophysiological and psychosocial aspects of fibromyalgia discussed the collected evidence and progressively refined and conceptualized its interpretation. This work constitutes an essential step towards the development of a model capable of integrating the main factors implicated in fibromyalgia into a single, unified construct which appears indispensable to foster the understanding, assessment, and intervention for fibromyalgia.

Keywords: Dynamic interplay; Fibromyalgia; Integrative; Neurophysiological abnormalities; Psychosocial processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Fibromyalgia*
  • Humans
  • Models, Biopsychosocial*