A ratiometric, colorimetric fluorescent probe with a large emission shift for the rapid detection of diethyl chlorophosphate

Xue-Shuang Yu; Rui Zuo; Ming-Ye Shuai; Xu Feng; Yu Peng; Ya-Wen Wang

doi:10.1039/d3ob00505d

A ratiometric, colorimetric fluorescent probe with a large emission shift for the rapid detection of diethyl chlorophosphate

Org Biomol Chem. 2023 Jun 7;21(22):4667-4671. doi: 10.1039/d3ob00505d.

Authors

Xue-Shuang Yu¹, Rui Zuo¹, Ming-Ye Shuai¹, Xu Feng², Yu Peng¹, Ya-Wen Wang¹

Affiliations

¹ School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. pengyu@swjtu.edu.edu.cn.
² Jiulongpo Center for Disease Control and Prevention of Chongqing, Chongqing 400039, People's Republic of China.

PMID: 37212433
DOI: 10.1039/d3ob00505d

Abstract

A new ratiometric and colorimetric probe (SWJT-16) based on the isophorone skeleton to detect diethyl chlorophosphite (DCP), a nerve agent mimic, was designed and synthesized. SWJT-16 underwent a nucleophilic substitution reaction with DCP in DMF, leading to a large emission shift (Δλ_em = 174 nm) accompanied by a significant color change from blue to yellow under visible light. All these changes occurred within 6 seconds, faster than those of most reported ratiometric fluorescent probes for DCP. Furthermore, SWJT-16 was successfully employed to monitor gaseous DCP.