Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers

Ce Chao; Renzhe Tang; Jiamin Zhao; Dongmei Di; Yongxiang Qian; Bin Wang

doi:10.3389/fcell.2023.1087337

Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers

Front Cell Dev Biol. 2023 May 5:11:1087337. doi: 10.3389/fcell.2023.1087337. eCollection 2023.

Authors

Ce Chao¹, Renzhe Tang¹, Jiamin Zhao², Dongmei Di¹, Yongxiang Qian¹, Bin Wang¹

Affiliations

¹ Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
² Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Abstract

Long non-coding RNAs (lncRNAs) play vital roles in regulating epigenetic mechanisms and gene expression levels, and their dysregulation is closely associated with a variety of diseases such as cancer. Several studies have demonstrated that lncRNAs are dysregulated during tumor progression. Recently, the MYC-induced long non-coding RNA MINCR, a newly identified lncRNA, has been demonstrated to act as an oncogene in different cancers, including gallbladder cancer, hepatocellular cancer, colorectal cancer, non-small cell lung cancer, oral squamous cell carcinoma, nasopharyngeal cancer, and glioma. Moreover, MINCR has been reported to act as a biomarker in the prognosis of patients with different cancers. In this review, we summarize and analyze the oncogenic roles of MINCR in a variety of human cancers in terms of its clinical significance, biological functions, cellular activities, and regulatory mechanism. Our analysis of the literature suggests that MINCR has potential as a novel biomarker and therapeutic target in human cancers.

Keywords: MINCR; biomarker; human cancers; lncRNA; treatment.

Publication types

Review

Grants and funding

The study was supported by the Young Talent Development Plan of Changzhou Health Commission (CZQM2020004), Basic Research Project of Changzhou science and Technology Bureau (CJ20200104), Social Development Projects of Changzhou science and Technology Bureau (CE20205039), and Science and Technology Project of Changzhou Health Commission (WZ202106).