Association between smoking and intracranial artery dissection in patients aged less than 50 years: A propensity score-matched analysis

Jiangli Han; Jigang Chen; Xin Tong; Mingyang Han; Fei Peng; Hao Niu; Lang Liu; Fei Liu; Aihua Liu

doi:10.18332/tid/162380

Association between smoking and intracranial artery dissection in patients aged less than 50 years: A propensity score-matched analysis

Tob Induc Dis. 2023 May 18:21:62. doi: 10.18332/tid/162380. eCollection 2023.

Authors

Jiangli Han¹, Jigang Chen², Xin Tong², Mingyang Han³, Fei Peng², Hao Niu², Lang Liu³, Fei Liu^{3

4}, Aihua Liu^{2

3}

Affiliations

¹ Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou, China.
² Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
³ Department of Neurosurgery, the Third Xiangya Hospital, Central South University, Changsha, China.
⁴ Department of Neurosurgery, the Fifth Affiliated Hospital of Sun Yatsen University, Zhuhai, China.

Abstract

Introduction: Smoking is a common risk factor for stroke in the young population. Intracranial artery dissection (ICAD) is a major cause of stroke in this population. However, the association between smoking and ICAD in young patients is not well characterized. We aimed to evaluate the association between smoking and ICAD in young individuals using propensity score-matched analysis.

Methods: We conducted a retrospective study of consecutive patients aged <50 years with ICAD who were admitted to Beijing Tiantan Hospital between January 2016 and December 2020. Patients with other non-atherosclerotic/non-aneurysmal cerebrovascular diseases were selected as controls. Propensity score matching was based on age and sex. Smoking and other vascular risk factors were compared between the two groups.

Results: The ICAD and control group included 120 and 197 patients, respectively. Propensity score matching resulted in 70 matched pairs. Smoking was the only significant factor association with ICAD in the matched cohort (p=0.031).

Conclusions: In this propensity score-matched analysis, smoking showed a positive association with ICAD in young patients with common cerebrovascular diseases that were neither atherosclerotic nor aneurysmal. Further studies are required to investigate the predictive role of smoking for ICAD in the young population.

Keywords: angiography; atherosclerosis; dissection; risk factors; stroke.