Reduced Interference and Serial Dependency Effects for Naming in Older but Not Younger Adults after 1 Hz rTMS of Right Pars Triangularis

Jonathan H Drucker; Charles M Epstein; Keith M McGregor; Kyle Hortman; Kaundinya S Gopinath; Bruce Crosson

doi:10.1162/nol_a_00063

Reduced Interference and Serial Dependency Effects for Naming in Older but Not Younger Adults after 1 Hz rTMS of Right Pars Triangularis

Neurobiol Lang (Camb). 2022 Mar 17;3(2):256-271. doi: 10.1162/nol_a_00063. eCollection 2022.

Authors

Jonathan H Drucker^{1

2

3}, Charles M Epstein², Keith M McGregor^{1

2}, Kyle Hortman¹, Kaundinya S Gopinath⁴, Bruce Crosson^{1

2

5}

Affiliations

¹ VA Rehabilitation Research & Development Center for Visual and Neurocognitive Rehabilitation, Decatur, GA, USA.
² Department of Neurology, Emory University, Atlanta, GA, USA.
³ Aptima, Inc., Woburn, MA, USA.
⁴ Department of Radiology, Emory University, Atlanta, GA, USA.
⁵ Department of Psychology, Georgia State University, Atlanta, GA, USA.

Abstract

1 Hz repetitive transcranial magnetic stimulation (rTMS) was used to decrease excitability of right pars triangularis (R PTr) to determine whether increased R PTr activity during picture naming in older adults hampers word finding. We hypothesized that decreasing R PTr excitability would reduce interference with word finding, facilitating faster picture naming. 15 older and 16 younger adults received two rTMS sessions. In one, speech onset latencies for picture naming were measured after both sham and active R PTr stimulation. In the other session, sham and active stimulation of a control region, right pars opercularis (R POp), were administered before picture naming. Order of active vs. sham stimulation within session was counterbalanced. Younger adults showed no significant effects of stimulation. In older adults, a trend indicated that participants named pictures more quickly after active than sham R PTr stimulation. However, older adults also showed longer responses during R PTr than R POp sham stimulation. When order of active vs. sham stimulation was modeled, older adults receiving active stimulation first had significantly faster responding after active than sham R PTr stimulation and significantly faster responding after R PTr than R POp stimulation, consistent with experimental hypotheses. However, older adults receiving sham stimulation first showed no significant differences between conditions. Findings are best understood, based on previous studies, when the interaction between the excitatory effects of picture naming and the inhibitory effects of 1 Hz rTMS on R PTr is considered. Implications regarding right frontal activity in older adults and for design of future experiments are discussed.

Keywords: Broca’s area; aging; inhibition; language; neuromodulation; repetitive transcranial magnetic stimulation.