This study was aimed at investigating the role of alcohol and drug use in relation to emotional self-regulation in 15- and 18-year-old adolescents. It was found that the stronger this link, the heavier the use of alcohol and marijuana. The findings suggest that the experience of strained social relationships and a heightened sense of powerlessness/helplessness may induce adolescents to rely more heavily on substance use as a means of emotional self-regulation which requires little effort and ability, promises instant effects, and provides a sense of control.