Depression dependent parkinsonism: case report

Int J Psychiatry Med. 1986-1987;16(1):85-90. doi: 10.2190/ghrn-7rwe-lpd8-rfp7.


With increasing depression a patient's Parkinsonian tremors increased. With successful treatment of the patient's depression with imipramine, the tremors disappeared, but slowly began again after drug noncompliance resulted in recurrence of depression. Evidence suggesting a relationship between depression and extrapyramidal dysfunction is discussed. The need for a greater understanding of the role of the extrapyramidal system in emotion and behavior and the connections between the extrapyramidal system to limbic and cortical structures are noted.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Basal Ganglia Diseases / complications
  • Cerebral Cortex / physiology
  • Depressive Disorder / complications*
  • Depressive Disorder / drug therapy
  • Emotions / physiology
  • Humans
  • Imipramine / therapeutic use
  • Limbic System / physiology
  • Male
  • Parkinson Disease / complications*
  • Receptors, Dopamine / physiology


  • Receptors, Dopamine
  • Imipramine