Hydrophobic cyclic dipeptides as M+/Cl- carriers

Chem Commun (Camb). 2023 Jun 6;59(46):7068-7071. doi: 10.1039/d3cc02132g.


Transmembrane ion-pair co-transport using synthetic transporters is non-trivial. Herein, cyclic dipeptide ion-carriers with dangling ester motifs to bind cations and amide-NH to bind anions are reported. The pendant lipophilic norbornene units aid in membrane insertion to achieve MCl co-transport with this simple design.