Determination of 24 sulfonamide antibiotics in instant pastries by modified QuEChERS coupled with ultra performance liquid chromatography-tandem mass spectrometry

J Food Drug Anal. 2023 Mar 15;31(1):73-84. doi: 10.38212/2224-6614.3434.

Abstract

There were few reports about antibiotic residues in egg-containing products. In the study, an effective method for the simultaneous determination of 24 sulfonamide antibiotics in two instant pastries based on a modified QuEChERS sample preparation technique coupled with ultra performance liquid chromatography-tandem mass spectrometry was developed. The results show that the average recoveries of the SAs at 5, 10, and 50 μg kg-1 levels were 67.6%-103.8%, with relative standard deviations (RSD) of 0.80-9.23%. The limit of detections (LODs) and limit of quantitations (LOQs) were 0.01-0.14 μg kg-1 and 0.02-0.45 μg kg-1, respectively. This method was suitable for analysis of 24 SAs in instant pastries.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Chromatography, Liquid
  • Eggs
  • Sulfonamides / chemistry
  • Sulfonamides / pharmacology
  • Tandem Mass Spectrometry

Substances

  • Sulfonamides
  • Anti-Bacterial Agents

Grants and funding

This work was supported by the Key Research and Development Program of Hebei Province, China (223777116D) and the Central Government Guides the Development of Local Science and Technology Project of Hebei Province (226Z7708G).