Exploring the benefits of functionally graded carbon nanotubes (FG-CNTs) as a platform for targeted drug delivery systems

Abstract

Background and objective: Modern therapeutic systems have benefited from the use of functionally graded carbon nanotubes (FG-CNTs) to enhance their efficiency. Various studies have shown that the study of dynamic response and stability of fluid-conveying FG-nanotubes can be improved by considering a Multiphysics framework for the modeling of such a complex biological environment. However, despite noticing important aspects in modeling, the previous studies have drawbacks such as underrepresenting the effect of varying composition of the nanotube on magnetic drug release in drug delivery systems. The present work has the novelty of studying the combined effects of fluid flow, magnetic field, small-scale parameters, and functionally graded material on the performance of FG-CNTs for drug delivery applications. Additionally, the lack of an inclusive parametric study is resolved in the present study by evaluating the significance of different geometrical and physical parameters. As such, the achievements support the development of an efficient drug delivery treatment.

Methods: The Euler-Bernoulli beam theory is implemented to model the nanotube and Hamilton's principle based on Eringen's nonlocal elasticity theory is used to derive the constitutive equations of motion. To add the effect of slip velocity on the CNT's wall, a correction factor is applied to velocity based on the Beskok-Karniadakis model.

Results: demonstrate that the dimensionless critical flow velocity increases by 227% as the magnetic field intensity increases from 0 to 20 T, and improves the system stability. On the contrary, drug loading on the CNT has the opposite effect, as the critical velocity decreases from 10.1 to 8.38 using a linear function for drug loading, and it decreases to 7.95 using an exponential function. By employing a hybrid load distribution, an optimum material distribution can be achieved.

Conclusions: To benefit from the potential of CNTs in drug delivery systems while minimizing the instability problems, a suitable design for the drug loading is required prior to the clinical implementation of the nanotube.

Keywords: Drug delivery; Functionally graded carbon nanotube; Magnetic drug release; Nonlocal theory; Stability analysis.