Obesogens and Obesity: State-of-the-Science and Future Directions Summary from a HEEDS Workshop

Am J Clin Nutr. 2023 May 23;S0002-9165(23)63923-1. doi: 10.1016/j.ajcnut.2023.05.024. Online ahead of print.


On September 7-8, 2022, Healthy Environment and Endocrine Disruptors Strategies (HEEDS), a program of Environmental Health Sciences, convened a scientific workshop of relevant stakeholders involved in obesity, toxicology, or obesogen research to review the state of the science regarding the role of obesogenic chemicals that might be contributing to the obesity pandemic. The workshop's objectives were to examine the evidence supporting the hypothesis that obesogens contribute to the etiology of human obesity; to discuss opportunities for improved understanding, acceptance, and dissemination of obesogens as contributors to the obesity pandemic; and to consider the need for future research and potential mitigation strategies. This report details the discussions, key areas of agreement and future opportunities to prevent obesity. The attendees agreed that environmental obesogens are real, significant, and a contributor at some level to weight gain at the individual level and to the global obesity and metabolic disease pandemic at a societal level moreover, it is at least, in theory, remediable.