Therapeutic effects of mesoderm introduction of compound glycyrrhizin injection on the treatment of rosacea

Skin Res Technol. 2023 May;29(5):e13328. doi: 10.1111/srt.13328.


Objectives: This study aims to introduce compound glycyrrhizin injection for the treatment of rosacea by mesoderm therapy, and further analyze the therapeutic and aesthetic effects of this treatment method and its impact on the dermatological quality of life index, which provides new ideas and methods for cosmetic dermatology treatment of rosacea.

Methods: The recruited rosacea patients were divided into Control group (n = 58) and observation group (n = 58) according to the random number table. The control group was treated with topical metronidazole clindamycin liniment, and the study group was additionally used mesoderm introduction of compound glycyrrhizin injection. The transepidermal water loss (TEWL), water content in corneum, and dermatology life quality index (DLQI) in rosacea patients were evaluated.

Results: Our results showed that the scores of erythema, flushing, telangiectasia, and papulopustule were significantly reduced in the observation group. In addition, the observation group significantly decreased TEWL and increased the water content of the stratum corneum. Furthermore, the observation group significantly reduced the DLQI of rosacea patients compared to the control group.

Conclusion: The use of mesoderm therapy combined with compound glycyrrhizic acid has a therapeutic effect on facial rosacea and improves patient satisfaction.

Keywords: compound glycyrrhizin injection; dermatology life quality index (DLQI); mesoderm therapy; rosacea; transepidermal water loss (TEWL).

MeSH terms

  • Erythema / drug therapy
  • Glycyrrhizic Acid* / therapeutic use
  • Humans
  • Metronidazole / therapeutic use
  • Quality of Life
  • Rosacea* / drug therapy


  • Glycyrrhizic Acid
  • Metronidazole