Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application

J Cardiovasc Dev Dis. 2023 May 17;10(5):220. doi: 10.3390/jcdd10050220.


Imaging modalities are increasingly being used to evaluate the underlying pathophysiology of heart failure. Positron emission tomography (PET) is a non-invasive imaging technique that uses radioactive tracers to visualize and measure biological processes in vivo. PET imaging of the heart uses different radiopharmaceuticals to provide information on myocardial metabolism, perfusion, inflammation, fibrosis, and sympathetic nervous system activity, which are all important contributors to the development and progression of heart failure. This narrative review provides an overview of the use of PET imaging in heart failure, highlighting the different PET tracers and modalities, and discussing fields of present and future clinical application.

Keywords: PET; heart failure; metabolic imaging; microvascular dysfunction; radionuclide.

Publication types

  • Review

Grants and funding

This research received no external funding.