Emerging concepts towards a translational framework in Alzheimer's disease

Neurosci Biobehav Rev. 2023 Sep:152:105246. doi: 10.1016/j.neubiorev.2023.105246. Epub 2023 May 24.


Over the past decades, significant efforts have been made to understand the precise mechanisms underlying the pathogenesis of Alzheimer's disease (AD), the most common cause of dementia. However, clinical trials targeting AD pathological hallmarks have consistently failed. Refinement of AD conceptualization, modeling, and assessment is key to developing successful therapies. Here, we review critical findings and discuss emerging ideas to integrate molecular mechanisms and clinical approaches in AD. We further propose a refined workflow for animal studies incorporating multimodal biomarkers used in clinical studies - delineating critical paths for drug discovery and translation. Addressing unresolved questions with the proposed conceptual and experimental framework may accelerate the development of effective disease-modifying strategies for AD.

Keywords: Alzheimer's disease; Animal models; Clinical trials; Molecular mechanisms; Translational framework.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease* / pathology
  • Animals
  • Biomarkers
  • Drug Discovery


  • Biomarkers