A protocol for the evaluation of new psychoactive drugs in man

Methods Find Exp Clin Pharmacol. 1986 May;8(5):313-20.


A protocol is presented that has proven effective in the determination, in man, of the psychotomimetic potency and qualitative nature of action of a new drug. It involves a minimum of animal screening, but relies heavily upon the use of experienced human subjects. This procedure has been successful in the discovery of over 200 novel CNS-active agents.

MeSH terms

  • Animals
  • Antidepressive Agents / therapeutic use
  • Drug Evaluation
  • Drug Evaluation, Preclinical
  • Drug Therapy, Combination
  • Hallucinogens / pharmacology
  • Humans
  • Mental Disorders / drug therapy
  • Psychotropic Drugs / pharmacology*
  • Psychotropic Drugs / therapeutic use
  • Psychotropic Drugs / toxicity
  • Research Design
  • Sensation / drug effects


  • Antidepressive Agents
  • Hallucinogens
  • Psychotropic Drugs