Abstract
A protocol is presented that has proven effective in the determination, in man, of the psychotomimetic potency and qualitative nature of action of a new drug. It involves a minimum of animal screening, but relies heavily upon the use of experienced human subjects. This procedure has been successful in the discovery of over 200 novel CNS-active agents.
MeSH terms
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Animals
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Antidepressive Agents / therapeutic use
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Drug Evaluation
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Drug Evaluation, Preclinical
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Drug Therapy, Combination
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Hallucinogens / pharmacology
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Humans
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Mental Disorders / drug therapy
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Psychotropic Drugs / pharmacology*
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Psychotropic Drugs / therapeutic use
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Psychotropic Drugs / toxicity
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Research Design
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Sensation / drug effects
Substances
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Antidepressive Agents
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Hallucinogens
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Psychotropic Drugs