Cryoneurolysis of alveolar nerves for chronic dental pain: A new technique and a case series

Pain Pract. 2023 Sep;23(7):851-854. doi: 10.1111/papr.13254. Epub 2023 May 27.


Background: Chronic neuropathic dental pain has a poor prognosis with a low chance of significant spontaneous improvement. Local or oral therapies may be efficient, however short in terms of duration with potential side effects. Cryoneurolysis has been described to prevent acute postoperative pain or to treat some chronic pain conditions; however, application to dental orofacial pain has not been reported so far.

Case series: Following a positive diagnostic block on the corresponding alveolar nerve, neuroablation was performed using a cryoprobe on three patients suffering from persistent pain after a dental extraction and 1 after multiple tooth surgeries. The effect of treatment was assessed using a Pain Numeric Rating Scale (NRS) and determined by changes in medication dosage and quality of life at day 7 and 3 months. Two patients experienced more than 50% of pain relief at 3 months, 2 by 50%. One patient was able to wean off pregabalin medication, one decreased amitriptyline by 50%, and one decreased tapentadol by 50%. No direct complications were reported. All of them mentioned improvement in sleep and quality of life.

Conclusion: Cryoneurolysis on alveolar nerves is a safe and easy-to-use technique allowing prolonged neuropathic pain relief after dental surgery.

Keywords: cryoneurolysis; orofacial pain; persistent postoperative pain.

Publication types

  • Case Reports

MeSH terms

  • Chronic Pain* / etiology
  • Chronic Pain* / surgery
  • Humans
  • Neuralgia* / etiology
  • Neuralgia* / surgery
  • Pain Management / methods
  • Pregabalin / therapeutic use
  • Quality of Life
  • Tapentadol / therapeutic use


  • Pregabalin
  • Tapentadol