Convenient Synthesis of Salicylanilide Sulfonates from 1,2,3-Benzotriazin-4(3 H)-ones and Organosulfonic Acids via Denitrogenative Cross-Coupling

Ramaraju Korivi; Kanagaraj Madasamy; Popuri Sureshbabu; Subramaniyan Mannathan

doi:10.1021/acsomega.3c02165

Convenient Synthesis of Salicylanilide Sulfonates from 1,2,3-Benzotriazin-4(3 H)-ones and Organosulfonic Acids via Denitrogenative Cross-Coupling

ACS Omega. 2023 May 9;8(20):18306-18311. doi: 10.1021/acsomega.3c02165. eCollection 2023 May 23.

Authors

Ramaraju Korivi¹, Kanagaraj Madasamy¹, Popuri Sureshbabu¹, Subramaniyan Mannathan¹

Affiliation

¹ Department of Chemistry, SRM University-AP, Amaravati 522502, Andhra Pradesh, India.

Abstract

An efficient and straightforward approach to synthesize salicylanilide aryl and alkyl sulfonates from 1,2,3-benzotriazin-4(3H)-ones and organosulfonic acids is described. This protocol is operationally simple and scalable, exhibits a broad substrate scope with high functional group tolerance, and affords the desired products in good to high yield. Application of the reaction is also demonstrated by converting the desired product to synthetically useful salicylamides in high yields.