Evaluation of a Simple Low-cost Intervention to Empower People with CKD to Reduce Their Dietary Salt Intake: OxCKD1, a Multicenter Randomized Controlled Trial

Kidney360. 2023 Jul 1;4(7):890-898. doi: 10.34067/KID.0000000000000160. Epub 2023 May 31.


Key Points:

  1. A randomized controlled trial demonstrates that a simple and cheap 1-month intervention empowers people with CKD to lower their dietary salt intake.

  2. The effect of the intervention persisted after the intervention finished.

Background: To evaluate the efficacy of a simple low-cost intervention to empower people with CKD to reduce their dietary salt intake.

Methods: A randomized controlled trial in primary and secondary care comparing the OxSalt care bundle intervention versus standard care for 1 month. Participants were people with CKD and an eGFR >20 ml/min per 1.73 m2 and were recruited from primary and secondary care. The primary outcome was a reduction in dietary salt intake, as assessed by 24-hour urinary sodium excretion, after 1 month of the intervention.

Results: Two hundred and one participants were recruited. Dietary salt intake, as assessed from 24-hour urine sodium excretion, fell by 1.9 (±2.9) g/d in the intervention group compared with 0.4 (±2.7) g/d in the control group (P < 0.001). Salt intake was still reduced to a lesser extent over the following year in the intervention group.

Conclusions: A short, low-cost, easily delivered intervention empowers people with CKD to reduce their dietary salt intake.

Trial registration: ClinicalTrials.gov NCT01552317.

Publication types

  • Randomized Controlled Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Pressure
  • Humans
  • Hypertension*
  • Nutritional Status
  • Renal Insufficiency, Chronic* / therapy
  • Sodium Chloride, Dietary / adverse effects


  • Sodium Chloride, Dietary

Associated data

  • ClinicalTrials.gov/NCT01552317