Molecular Breast Imaging and Positron Emission Mammography

Miral M Patel; Beatriz Elena Adrada; Amy M Fowler; Gaiane M Rauch

doi:10.1016/j.cpet.2023.04.005

Molecular Breast Imaging and Positron Emission Mammography

PET Clin. 2023 Oct;18(4):487-501. doi: 10.1016/j.cpet.2023.04.005. Epub 2023 May 29.

Authors

Miral M Patel¹, Beatriz Elena Adrada², Amy M Fowler³, Gaiane M Rauch⁴

Affiliations

¹ Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, CPB5.3208, Houston, TX 77030, USA. Electronic address: MPatel6@mdanderson.org.
² Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, CPB5.3208, Houston, TX 77030, USA.
³ Department of Radiology, Section of Breast Imaging and Intervention, University of Wisconsin - Madison, 600 Highland Avenue, Madison, WI 53792-3252, USA; Department of Medical Physics, University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792-3252, USA.
⁴ Department of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Unit 1473, Houston, TX 77030, USA; Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Unit 1473, Houston, TX 77030, USA.

PMID: 37258343
DOI: 10.1016/j.cpet.2023.04.005

Abstract

There is growing interest in application of functional imaging modalities for adjunct breast imaging due to their unique ability to evaluate molecular/pathophysiologic changes, not visible by standard anatomic breast imaging. This has led to increased use of nuclear medicine dedicated breast-specific single photon and coincidence imaging systems for multiple indications, such as supplemental screening, staging of newly diagnosed breast cancer, evaluation of response to neoadjuvant treatment, diagnosis of local disease recurrence in the breast, and problem solving. Studies show that these systems maybe especially useful for specific subsets of patients, not well served by available anatomic breast imaging modalities.

Keywords: (99m)Tc-sestamibi; Breast Specific gamma imaging; Dedicated breast PET; FDG; Molecular breast imaging; Positron emission mammography.

Publication types

Review

MeSH terms

Breast / diagnostic imaging
Breast Neoplasms* / diagnostic imaging
Breast Neoplasms* / therapy
Electrons*
Female
Humans
Mammography / methods
Neoplasm Recurrence, Local
Radiopharmaceuticals

Substances

Radiopharmaceuticals