Expansion of ST2-expressing macrophages in a patient with bronchiolitis obliterans syndrome

Toyoshi Yanagihara; Kentaro Hata; Kunihiro Suzuki; Keisuke Matsubara; Kazufumi Kunimura; Kazuya Tsubouchi; Daisuke Eto; Hiroyuki Ando; Maki Uehara; Satoshi Ikegame; Yoshinori Fukui; Isamu Okamoto

doi:10.1183/23120541.00033-2023

Expansion of ST2-expressing macrophages in a patient with bronchiolitis obliterans syndrome

ERJ Open Res. 2023 May 30;9(3):00033-2023. doi: 10.1183/23120541.00033-2023. eCollection 2023 May.

Authors

Affiliations

¹ Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
² These authors contributed equally.
³ Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Abstract

This case study of a patient with BOS after HSCT found increased ST2⁺CD64⁺ macrophages in BALF, a potential therapeutic target for treatment-refractory BOS, and reduced CCR2⁺CD14⁺ monocytes compared to other lung disorders https://bit.ly/406Uyy9.