Roles of Krüppel-Like Transcription Factors KLF6 and KLF15 in Proximal Tubular Metabolism

Nephron. 2023;147(12):766-768. doi: 10.1159/000531336. Epub 2023 Jun 1.


Members of the Krüppel-like family of transcription factors are widely expressed, including in the kidney. Expression of some KLFs changes in acute kidney injury, and this may be adaptive or maladaptive, and result in effects on various cellular pathways. This mini-review will highlight the roles of KLF6 and KLF15 in control of proximal tubular cell metabolism.

Keywords: Acute kidney injury; Metabolism; Proximal tubule; Transcription factors.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Epithelial Cells / metabolism
  • Humans
  • Kidney / metabolism
  • Kruppel-Like Factor 6 / genetics
  • Kruppel-Like Factor 6 / metabolism
  • Kruppel-Like Transcription Factors* / genetics
  • Kruppel-Like Transcription Factors* / metabolism
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism


  • Kruppel-Like Transcription Factors
  • Transcription Factors
  • KLF6 protein, human
  • Kruppel-Like Factor 6
  • KLF15 protein, human