Time-resolved X-ray diffraction studies of the B in equilibrium D structural transition in the DNA double helix

Science. 1986 Jul 11;233(4760):195-7. doi: 10.1126/science.3726529.


Because of the relation between topology and function, there has been much interest in the structural transitions of the various conformations of DNA polymers. The x-ray fiber diffraction analysis system at the Daresbury Synchrotron Radiation Source was used to study the reversible transition between the B and D forms of the synthetic DNA poly[d(A-T)].poly[d(A-T)]. The gradual progression of conformations between these two forms indicates that the DNA double helix does not undergo a change of handedness during this transition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA*
  • Nucleic Acid Conformation
  • Poly dA-dT
  • X-Ray Diffraction*


  • Poly dA-dT
  • DNA