The vitamin K-antagonism of salicylate and warfarin

Thromb Res. 1986 Jun 15;42(6):727-36. doi: 10.1016/0049-3848(86)90109-x.

Abstract

When administered in high dosages, salicylate acts as a vitamin K-antagonist: it induces a decrease of the plasma concentration of the Gla-containing coagulation factors and an accumulation of microsomal substrates for vitamin K-dependent carboxylase in the liver and in the lung. In vitro the drugs inhibit the DTT-dependent reductases which mediate the reduction of vitamin K epoxide and vitamin K quinone. NADH-dependent reductase and vitamin K-dependent carboxylase are not inhibited.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Coagulation Factors / blood
  • Carboxy-Lyases / metabolism
  • Dose-Response Relationship, Drug
  • Liver / drug effects
  • Liver / metabolism
  • Lung / drug effects
  • Lung / metabolism
  • Oxidoreductases / metabolism
  • Rats
  • Salicylates / pharmacology*
  • Vitamin K / antagonists & inhibitors*
  • Warfarin / pharmacology*

Substances

  • Blood Coagulation Factors
  • Salicylates
  • Vitamin K
  • Warfarin
  • Oxidoreductases
  • Carboxy-Lyases