Endovascular repair of a common iliac artery aneurysm with an iliac branch device in a patient with vascular Ehlers-Danlos syndrome due to a null COL3A1 variant

Sherene Shalhub; Peter H Byers

doi:10.1016/j.jvscit.2023.101192

Endovascular repair of a common iliac artery aneurysm with an iliac branch device in a patient with vascular Ehlers-Danlos syndrome due to a null COL3A1 variant

J Vasc Surg Cases Innov Tech. 2023 Apr 20;9(2):101192. doi: 10.1016/j.jvscit.2023.101192. eCollection 2023 Jun.

Authors

Sherene Shalhub¹, Peter H Byers^{2

3}

Affiliations

¹ Division of Vascular and Endovascular Surgery, Department of Surgery, Oregon Health & Science University, Portland, OR.
² Department of Pathology, University of Washington, Seattle, WA.
³ Department of Medicine (Medical Genetics), University of Washington, Seattle, WA.

Abstract

Endovascular repair is avoided in patients with connective tissues disorders due to concerns for stent graft migration and endoleaks. We describe a successful endovascular repair of a common iliac artery aneurysm with a bifurcated aortoiliac stent graft and iliac branch endoprosthesis in a patient with Vascular Ehlers-Danlos syndrome (VEDS) due to a null COL3A1 variant. This case demonstrates that the VEDS genotype is associated with tissue integrity, specifically, individuals with VEDS due to null/haploinsufficiency variants, and adds to our understanding of endovascular repair in this population.

Keywords: Connective tissue disorder; Endovascular aortic repair; Genetic aortopathy; Iliac artery aneurysm; Iliac branch endoprosthesis; Vascular Ehlers-Danlos syndrome.

Publication types

Case Reports