The positive effect of spermidine in older adults suffering from dementia after 1 year

Wien Klin Wochenschr. 2023 Jun 7. doi: 10.1007/s00508-023-02226-z. Online ahead of print.


Background: A positive effect of the effect of a 3-month oral spermidine intake on memory performance has already been demonstrated. The continuation of this study aimed to examine whether there could be observed an improvement in memory performance after one year.

Method: 45 residents of the nursing home "Gepflegt Wohnen" in Hart bei Graz, Styria, Austria, were given a daily dose of 3.3 mg spermidine in their diet for one year.

Results: The comparison of the MMSE test results at baseline and after one year demonstrated a significant (p < 0.001) difference. The mean improvement is 5 points.

Conclusion: The new results confirm the already proven positive effect of oral spermidine intake on memory performance.

Keywords: Alzheimer; Biogen amines; CERAD-Plus; Memory perfomance; Nutrition.