Logistic analysis of risk factors in acute retinopathy of prematurity

Am J Ophthalmol. 1986 Jul 15;102(1):1-6. doi: 10.1016/0002-9394(86)90200-x.


In a prospective study of 328 high-risk neonates, we used computer-assisted logistic regression of 47 potential risk factors to study acute retinopathy of prematurity. Only four factors were significant in the logistic regression equation: ventilator hours, xanthine administration, birthweight, and maternal bleeding. Xanthine administration was identified as a new independent and significant (P less than .0001) predictor of acute retinopathy of prematurity.

MeSH terms

  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature, Diseases / etiology*
  • Pregnancy
  • Respiration, Artificial / adverse effects
  • Retinal Diseases / etiology*
  • Uterine Hemorrhage / complications
  • Xanthines / adverse effects


  • Xanthines