Rationale and design of the ABOARD project (A Personalized Medicine Approach for Alzheimer's Disease)

Maria A E Dreves; Argonde C van Harten; Leonie N C Visser; Hanneke Rhodius-Meester; Sebastian Köhler; Minke Kooistra; Janne M Papma; Madison I J Honey; Marco M Blom; Ellen M A Smets; Marjolein E de Vugt; Charlotte E Teunissen; Wiesje M van der Flier; ABOARD Consortium

doi:10.1002/trc2.12401

Rationale and design of the ABOARD project (A Personalized Medicine Approach for Alzheimer's Disease)

Alzheimers Dement (N Y). 2023 Jun 5;9(2):e12401. doi: 10.1002/trc2.12401. eCollection 2023 Apr-Jun.

Authors

Maria A E Dreves^{1

2}, Argonde C van Harten^{1

2

3}, Leonie N C Visser^{1

4

5

6}, Hanneke Rhodius-Meester^{1

2

7

8}, Sebastian Köhler⁹, Minke Kooistra¹⁰, Janne M Papma¹¹, Madison I J Honey^{2

3}, Marco M Blom¹⁰, Ellen M A Smets^{4

5}, Marjolein E de Vugt⁹, Charlotte E Teunissen^{2

3}, Wiesje M van der Flier^{1

2

12}; ABOARD Consortium

Affiliations

¹ Alzheimer Center Amsterdam Neurology Amsterdam UMC location VUmc Vrije Universiteit Amsterdam Amsterdam the Netherlands.
² Amsterdam Neuroscience Amsterdam UMC location VUmc Vrije Universiteit Amsterdam Amsterdam the Netherlands.
³ Neurochemistry Laboratory Department of Clinical Chemistry Vrije Universiteit Amsterdam Amsterdam the Netherlands.
⁴ Department of Medical Psychology Amsterdam UMC location AMC University of Amsterdam Amsterdam the Netherlands.
⁵ Amsterdam Public Health Research Institute Quality of Care Amsterdam UMC location AMC University of Amsterdam Amsterdam the Netherlands.
⁶ Division of Clinical Geriatrics Center for Alzheimer Research Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden.
⁷ Department of Internal Medicine Geriatric Medicine section Vrije Universiteit Amsterdam Amsterdam the Netherlands.
⁸ Department of Geriatric Medicine The Memory Clinic Oslo University Hospital Oslo Norway.
⁹ Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience Maastricht University Maastricht the Netherlands.
¹⁰ Alzheimer Nederland Amersfoort the Netherlands.
¹¹ Department of Neurology and Alzheimer Center Erasmus MC Erasmus MC University Medical Center Rotterdam the Netherlands.
¹² Department of Epidemiology and Data Science Amsterdam UMC location VUmc, Vrije Universiteit Amsterdam Amsterdam the Netherlands.

Abstract

The key to stopping Alzheimer's disease (AD) lies in the pre-dementia stages, with the goal to stop AD before dementia has started. We present the rationale and design of the ABOARD (A Personalized Medicine Approach for Alzheimer's Disease) project, which aims to invest in personalized medicine for AD. ABOARD is a Dutch public-private partnership of 32 partners, connecting stakeholders from a scientific, clinical, and societal perspective. The 5-year project is structured into five work packages on (1) diagnosis, (2) prediction, (3) prevention, (4) patient-orchestrated care, and (5) communication and dissemination. ABOARD functions as a network organization in which professionals interact cross-sectorally. ABOARD has a strong junior training program "Juniors On Board." Project results are shared with society through multiple communication resources. By including relevant partners and involving citizens at risk, patients, and their care partners, ABOARD builds toward a future with personalized medicine for AD.

Highlights: ABOARD (A Personalized Medicine Approach for Alzheimer's Disease) is a public-private research project executed by 32 partners that functions as a network organization.Together, the project partners build toward a future with personalized medicine for Alzheimer's disease.Although ABOARD is a Dutch consortium, it has international relevance.ABOARD improves diagnosis, prediction, prevention, and patient-orchestrated care.

Keywords: Alzheimer's disease; diagnosis; patient‐orchestrated care; personalized medicine; prediction; prevention.