Chronic pernio. A historical perspective of cold-induced vascular disease

Arch Intern Med. 1986 Aug;146(8):1589-92. doi: 10.1001/archinte.146.8.1589.


Chronic pernio, or cold-induced vascular disease, is an uncommon syndrome with a clinical resemblance to vasculitis or peripheral cholesterol embolization. We studied a case of chronic pernio in which the angiogram revealed extensive vascular changes indistinguishable from vasculitis; pathologic studies of previously reported cases have revealed a primary vasculopathy. The pathophysiology of chronic pernio may be cold-induced vessel damage leading to a secondary dermopathy. Our patient's condition improved once the correct diagnosis was established and appropriate therapy was instituted.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Angiography
  • Chilblains / diagnosis*
  • Chilblains / diagnostic imaging
  • Chilblains / physiopathology
  • Chronic Disease
  • Cold Temperature / adverse effects
  • Diagnosis, Differential
  • Female
  • Frostbite / diagnosis*
  • Hand / blood supply
  • Humans
  • Vascular Diseases / diagnosis
  • Vascular Diseases / etiology
  • Vasculitis / chemically induced