Association of a mixture of phthalates and phenols with frailty among middle-aged and older adults: A population-based cross-sectional study

Xianwei Guo; Dongdong Zhao; Jia Meng; Wenjing Hu; Birong Wu; Xingyue Wang; Wenqi Su; Muzi Meng; Guangbo Qu; Yehuan Sun

doi:10.1016/j.chemosphere.2023.139144

Association of a mixture of phthalates and phenols with frailty among middle-aged and older adults: A population-based cross-sectional study

Chemosphere. 2023 Sep:336:139144. doi: 10.1016/j.chemosphere.2023.139144. Epub 2023 Jun 9.

Authors

Xianwei Guo¹, Dongdong Zhao², Jia Meng¹, Wenjing Hu¹, Birong Wu¹, Xingyue Wang¹, Wenqi Su¹, Muzi Meng³, Guangbo Qu⁴, Yehuan Sun⁵

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China.
² Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China; The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China.
³ UK Program Site, American University of the Caribbean School of Medicine, Vernon Building Room 64, Sizer St, Preston PR1 1JQ, United Kingdom; Bronxcare Health System, 1650 Grand Concourse, The Bronx, NY 10457, USA.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. Electronic address: m17356519870@163.com.
⁵ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China. Electronic address: yhsun_ahmu_edu@yeah.net.

PMID: 37302498
DOI: 10.1016/j.chemosphere.2023.139144

Abstract

Background: Frailty is a complex geriatric syndrome caused by degenerative changes in the body or various chronic diseases. The use of personal care and consumer products is associated with a wide range of health outcomes, but its relationship with frailty remains unknown. Therefore, our primary aim was to explore the potential links between exposure to phenols and phthalates, either separately or in combination, and frailty.

Methods: The exposure levels of phthalates and phenols were evaluated through the measurement of metabolites in urine samples. Frailty state was assessed by a 36-item frailty index with values ≥ 0.25 indicating frailty. Weighted logistic regression was used to explore the relationship between individual chemical exposure and frailty. In addition, multi-pollutant strategies (WQS, Qgcomp, BKMR) were used to examine the joint effect of chemical mixture on frailty. A series of subgroup analyses and sensitivity analyses were conducted as well.

Results: In the multivariate logistic regression model, each unit increase in natural log-transformed BPA (OR: 1.21; 95%CI: 1.04, 1.40), MBP (OR: 1.25; 95%CI: 1.07, 1.46), MBzP (OR: 1.18; 95%CI: 1.03, 1.36), and MiBP (OR: 1.19; 95%CI: 1.03, 1.37) were significantly associated with higher odds of frailty. The results of the WQS and Qgcomp indicated that increasing quartiles of chemical mixture was associated with odds of frailty with ORs of 1.29 (95%CI: 1.01, 1.66) and 1.37 (95%CI: 1.06, 1.76). The weight of MBzP is dominant in both the WQS index and the positive weight of Qgcomp. In the BKMR model, the cumulative effect of chemical mixture was positively correlated with the prevalence of frailty.

Conclusions: In summary, higher levels of BPA, MBP, MBzP, and MiBP are significantly associated with higher odds of frailty. Our study provides preliminary evidence that phenol and phthalate biomarker mixture is positively associated with frailty, with MBzP contributing most to the positive association.

Keywords: BKMR; Frailty; Joint effect; Phenols; Phthalates; WQS.

MeSH terms

Aged
Cross-Sectional Studies
Environmental Exposure / analysis
Environmental Pollutants* / analysis
Frailty* / epidemiology
Humans
Middle Aged
Phenols / analysis
Phthalic Acids* / metabolism

Substances

phthalic acid
Phenols
Environmental Pollutants
Phthalic Acids