The effect of vitamin D3 supplementation on atrial fibrillation in generally healthy men and women: The Finnish Vitamin D Trial

Am Heart J. 2023 Oct:264:177-182. doi: 10.1016/j.ahj.2023.05.024. Epub 2023 Jun 10.

Abstract

Atrial fibrillation is a common cardiac arrhythmia with high morbidity risk. Observational studies suggest that vitamin D deficiency is associated with higher atrial fibrillation risk but there is limited evidence whether vitamin D supplementation could affect the risk. In these post hoc analyses from the Finnish Vitamin D Trial, we compared the incidence of atrial fibrillation with 5-year supplementation of vitamin D3 (1600 IU/d or 3200 IU/d) vs placebo. CLINICAL TRIAL REGISTRY NUMBER: ClinicalTrials.gov: NCT01463813, https://clinicaltrials.gov/ct2/show/NCT01463813.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Atrial Fibrillation* / drug therapy
  • Atrial Fibrillation* / epidemiology
  • Cholecalciferol / therapeutic use
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Finland / epidemiology
  • Humans
  • Male
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency* / complications
  • Vitamin D Deficiency* / drug therapy
  • Vitamin D Deficiency* / epidemiology
  • Vitamins / therapeutic use

Substances

  • Cholecalciferol
  • Vitamin D
  • Vitamins

Associated data

  • ClinicalTrials.gov/NCT01463813