The role of LIN28B in tumor progression and metastasis in solid tumor entities

Tabea Gewalt; Ka-Won Noh; Lydia Meder

doi:10.32604/or.2023.028105

The role of LIN28B in tumor progression and metastasis in solid tumor entities

Oncol Res. 2023 Apr 10;31(2):101-115. doi: 10.32604/or.2023.028105. eCollection 2023.

Authors

Tabea Gewalt^{1

2}, Ka-Won Noh³, Lydia Meder^{1

2

4}

Affiliations

¹ Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
² Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
³ Institute for Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
⁴ Mildred Scheel School of Oncology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Abstract

LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity. Under normal conditions, LIN28B is exclusively expressed in embryogenic stem cells, blocking differentiation and promoting proliferation. In addition, it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs. In malignancies, LIN28B is frequently overexpressed, which is associated with increased tumor aggressiveness and metastatic properties. In this review, we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.

Keywords: Cancer; EMT; LIN28B; Let-7; Metastasis; Resistance; Stemness.

Publication types

Review

MeSH terms

Cell Differentiation
Epithelial-Mesenchymal Transition / genetics
Humans
MicroRNAs* / genetics
Neoplasms* / genetics
RNA-Binding Proteins / genetics

Substances

MicroRNAs
LIN28B protein, human
RNA-Binding Proteins