Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report

Yoshio Nakano; Daisuke Sekinada; Gen Masuda; Chihiro Nishio; Koji Nishida; Norio Okamoto; Iwao Gohma; Yoshiki Esa

doi:10.1016/j.rmcr.2023.101878

Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report

Respir Med Case Rep. 2023 May 31:44:101878. doi: 10.1016/j.rmcr.2023.101878. eCollection 2023.

Authors

Yoshio Nakano¹, Daisuke Sekinada¹, Gen Masuda¹, Chihiro Nishio¹, Koji Nishida¹, Norio Okamoto¹, Iwao Gohma¹, Yoshiki Esa²

Affiliations

¹ Department of Respiratory Medicine, Sakai City Medical Center, 1-1-1, Ebaraji-cho, West Ward, Sakai City, Osaka Prefecture, 593-8304, Japan.
² Department of Neurology, Sakai City Medical Center, 1-1-1, Ebaraji-cho, West Ward, Sakai City, Osaka Prefecture, 593-8304, Japan.

Abstract

A 75-year-old man presented to our hospital with chronic sinusitis, bronchiectasis, and chronic lower respiratory tract infections. He began taking erythromycin in August, X-2. The chronic lower respiratory tract infection gradually worsened, and clarithromycin was started on May 11, X. He became aware of fever and numbness in his lower legs on June 4, X. The sign occurred soon after oral clarithromycin and blood tests showed an elevated eosinophil count and C-reactive protein (CRP) levels, positive MPO-ANCA antibodies, and positive for drug-induced lymphocyte stimulation test (DLST); we diagnosed eosinophilic granulomatosis with polyangiitis (EGPA) associated with clarithromycin administration.

Keywords: Clarithromycin; Drug-induced lymphocyte stimulation test; Eosinophilic granulomatosis with polyangiitis; MPO-ANCA antibodies.

Publication types

Case Reports