Further studies on the therapeutic effect of indomethacin on esophageal tumors

Cancer. 1986 Sep 1;58(5):1029-31. doi: 10.1002/1097-0142(19860901)58:5<1029::aid-cncr2820580508>3.0.co;2-d.


The effect of treatment with the nonsteroid anti-inflammatory drug indomethacin, was investigated in 250 3-month-old C57Bl female mice following induction of esophageal tumors with diethylnitrosamine (DEN). Already 3 months after DEN treatment, many esophageal tumors were committed to occur: despite discontinued DEN treatment, the number of tumors had increased significantly at 6 or 9 months of observation. Following 3 and 4 months of DEN administration, the development of many already committed esophageal tumors was significantly abrogated by treating the mice with indomethacin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diethylnitrosamine
  • Esophageal Neoplasms / chemically induced
  • Esophageal Neoplasms / pathology
  • Esophageal Neoplasms / prevention & control*
  • Female
  • Indomethacin / therapeutic use*
  • Mice
  • Mice, Inbred C57BL


  • Diethylnitrosamine
  • Indomethacin